OBJECTIVE: Our purpose was to determine whether prenatal colposcopy is beneficial in pregnant women with squamous atypia, atypical squamous cells of undetermined significance, or low-grade squamous intraepithelial lesions on an initial screening Papanicolaou smear. STUDY DESIGN: A retrospective chart review identified a cohort of
pregnant patients referred to the colposcopy clinic at Carolinas Medical Center between October 1991 and December 1994 with squamous atypia, atypical squamous cells of undetermined significance, or low-grade squamous intraepithelial lesions. Results of the colposcopic examination, cervical biopsy specimens, postpartum evaluation, and postpartum treatment were recorded. Descriptive statistics were used to tabulate numbers and percentages for all variables with 95% confidence intervals to
determine disease progression. RESULTS: Prenatal colposcopy was performed on 253 women during the study period. The colposcopic impression was normal or consistent with low-grade squamous intraepithelial lesions in 235 (93%) of the women. Of the 67 women who had a cervical biopsy, 6 had a histologic diagnosis of high-grade squamous intraepithelial lesions. Postpartum Papanicolaou smears were obtained in 224 patients; 71 (32%) were normal, 145 (65%) were unchanged, and 8 (3%)
showed high-grade squamous intraepithelial lesions. Of the 69 patients who had a postpartum cervical biopsy, 4 were found to have high-grade squamous intraepithelial lesions. Eight of the 10 women with biopsy-proved high-grade squamous intraepithelial lesions were compliant with treatment after delivery. Histologic examination of the cervix with tissue obtained by either loop conization or cold knife conization showed no evidence of invasive carcinoma. CONCLUSION: Squamous
atypia, atypical squamous cells of undetermined significance, or low-grade squamous intraepithelial lesions on a Papanicolaou smear in a pregnant patient does not require colposcopic evaluation during pregnancy. Progression of low-grade dysplasia to carcinoma during pregnancy is unusual, and no patient in this study was found to have invasive cancer. (Am J Obstet Gynecol 1997;177:298-302.) To read this article in full you will need to make a payment National Cancer Institute Workshop: interim guidelines for management of abnormal cervical cytology.
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Rapidly progressive squamous cell carcinoma of the cervix coexisting with human immunodeficiency virus infection: clinical opinion. Gynecol Oncol. 1991; 41: 255-258Article InfoFootnotes☆From the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Carolinas Medical Center ☆☆Reprint requests: Robert V. Higgins, MD, Department of Obstetrics and Gynecology, P.O. Box 32861, Charlotte, NC 28232-2861. ★6/6/82894 IdentificationDOI: https://doi.org/10.1016/S0002-9378(97)70190-X Copyright© 1997 Mosby, Inc. Published by Elsevier Inc. All rights reserved. ScienceDirectAccess this article on ScienceDirectRelated ArticlesCan you get pregnant with atypical squamous cells?The good news is, yes, you can still get pregnant. Treatment does not affect your fertility. If possible, check with your doctor or specialist before becoming pregnant to make sure you are up to date with your screenings. This way, you can have any necessary treatment beforehand.
Can pregnancy cause atypical cells in Pap smear?Topic Overview. Pregnancy does not seem to increase the progression of abnormal cervical cell changes. The presence of abnormal cervical cell changes or HPV does not affect the outcome of the pregnancy.
What happens if you have an abnormal Pap smear while pregnant?An abnormal Pap test may be evaluated further with colposcopy. This may be done during pregnancy or after delivery. If colposcopy shows normal tissue, then a repeat Pap test or colposcopy may be done later. Having a second test depends on the type of abnormalities reported on the first Pap test.
Can you have a baby if you have abnormal cells?Most women can have a normal pregnancy after treatment for abnormal cells but rarely there are problems. You might need treatment to keep future pregnancies safe.
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Atypical squamous cells of undetermined significance pregnancy
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