difference psoriatic arthritis rheumatoid arthritis

What is the difference between psoriatic arthritis and rheumatoid arthritis

Distinguishing rheumatoid arthritis from psoriatic arthritis

Joseph F Merola et al. RMD Open. 2018.

Free PMC article

Abstract

Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) have key differences in clinical presentation, radiographic findings, comorbidities and pathogenesis to distinguish between these common forms of chronic inflammatory arthritis. Joint involvement is typically, but not always, asymmetric in PsA, while it is predominantly symmetric in RA. Bone erosions, without new bone growth, and cervical spine involvement are distinctive of RA, while axial spine involvement, psoriasis and nail dystrophy are distinctive of PsA. Patients with PsA typically have seronegative test findings for rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies, while approximately 80% of patients with RA have positive findings for RF and CCP antibodies. Although there is overlap in the pathogenesis of PsA and RA, differences are also present that affect the efficacy of treatment. In PsA, levels of interleukin (IL)-1β, IL-6, IL-17, IL-22, IL-23, interferon-γ and tumour necrosis factor-α (TNF-α) are elevated, and in RA, levels of IL-1, IL-6, IL-22, IL-33, TNF-α, chemokine ligand 11 and chemokine C-X-C motif ligand 13 are elevated. Differences in the pathogenesis of RA and PsA translate into some variances in the specificity and efficacy of therapies.

Keywords: inflammatory disease; psoriatic arthritis; rheumatoid arthritis.

Conflict of interest statement

Competing interests: JFM is a consultant for Biogen Idec, AbbVie, Eli Lilly, Novartis, Pfizer, Janssen, UCB, Samumed, Science 37, Celgene, Sanofi Regeneron, Merck and GSK; speaker for AbbVie; an investigator for Biogen Idec, Pfizer, Sanofi Regeneron, Incyte and Novartis; licensed outcome measure to AbbVie and Lilly. LRE has no competing interests to disclose. RF has consulted and served as an investigator for AbbVie, Acea, Amgen, Augurex, BMS, Boehringer Ingelheim, Celgene, Genentech, GSK, Janssen, Eli Lilly, EMD Merck Serono, Novartis, Pfizer, Samumed, Roche, Sanofi Genzyme and UCB.

Figures

Figure1

Pathogenesisof PsA and RA. Reprinted from Coates et al and Perera et al. IFN, interferon; IL, interleukin; MHC, major histocompatibility complex; PsA, psoriatic arthritis; Pso, psoriasis; RA, rheumatoid arthritis; TCR, T cell receptor; TGF-β, transforming growth factor-β; Th, T helper; TNF-α, tumour necrosis factor-α.

Similar articles

  • Anti-CCP antibodies in rheumatoid arthritis and psoriatic arthritis.

    Inanc N, Dalkilic E, Kamali S, Kasapoglu-Günal E, Elbir Y, Direskeneli H, Inanc M. Inanc N, et al. Clin Rheumatol. 2007 Jan;26(1):17-23. doi: 10.1007/s10067-006-0214-5. Epub 2006 Mar 15. Clin Rheumatol. 2007. PMID: 16538391

  • Anti-cyclic citrullinated peptide antibodies and IL-23p19 in psoriatic arthritis.

    Shibata S, Tada Y, Komine M, Hattori N, Osame S, Kanda N, Watanabe S, Saeki H, Tamaki K. Shibata S, et al. J Dermatol Sci. 2009 Jan;53(1):34-9. doi: 10.1016/j.jdermsci.2008.06.008. Epub 2008 Aug 26. J Dermatol Sci. 2009. PMID: 18752933

  • Low frequency of anticyclic citrullinated peptide antibodies in psoriatic arthritis but not in cutaneous psoriasis.

    Candia L, Marquez J, Gonzalez C, Santos AM, Londoño J, Valle R, Zabaleta J, Yaqub Z, Espinoza LR. Candia L, et al. J Clin Rheumatol. 2006 Oct;12(5):226-9. doi: 10.1097/rhu.0000242779.73390.51. J Clin Rheumatol. 2006. PMID: 17023808

  • Anti-cyclic citrullinated peptide antibodies in psoriatic arthritis--cross-sectional study and literature review.

    Popescu C, Zofotă S, Bojincă V, Ionescu R. Popescu C, et al. J Med Life. 2013;6(4):376-82. Epub 2013 Dec 25. J Med Life. 2013. PMID: 24701255 Free PMC article. Review.

  • Psoriatic Arthritis.

    Tiwari V, Brent LH. Tiwari V, et al. 2022 Jun 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. 2022 Jun 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 31613490 Free Books & Documents.

Cited by

  • Burden and Disease Characteristics of Psoriatic Arthritis at a Tertiary Center.

    Attar S, Almanmmas AM, Alamri SM, Sindi AW, Jobah MT, Bader MA, Alghamdi AK, Sahhaf MZ, AlAmoudi TA. Attar S, et al. Cureus. 2022 Jul 27;14(7):e27359. doi: 10.7759/cureus.27359. eCollection 2022 Jul. Cureus. 2022. PMID: 36043001 Free PMC article.

  • Comparison of the axillary lymph node between rheumatoid arthritis and psoriatic arthritis with computed tomography.

    Fukuda T, Kayama R, Ogiwara S, Yonenaga T, Ojiri H. Fukuda T, et al. Acta Radiol Open. 2022 Jul 13;11(7):20584601221112616. doi: 10.1177/20584601221112616. eCollection 2022 Jul. Acta Radiol Open. 2022. PMID: 35846390 Free PMC article.

  • The effects of custom-made foot orthoses on foot pain, foot function, gait function, and free-living walking activities in people with psoriatic arthritis (PsA): a pre-experimental trial.

    Walha R, Dagenais P, Gaudreault N, Beaudoin-Côté G, Boissy P. Walha R, et al. Arthritis Res Ther. 2022 May 25;24(1):124. doi: 10.1186/s13075-022-02808-8. Arthritis Res Ther. 2022. PMID: 35614481 Free PMC article.

  • Analysis of the Pharmacoutilization of Biological Drugs in Psoriatic Arthritis Patients: A Real-World Retrospective Study Among an Italian Population.

    Perrone V, Losi S, Filippi E, Mezzetti M, Dovizio M, Sangiorgi D, Degli Esposti L. Perrone V, et al. Rheumatol Ther. 2022 Jun;9(3):875-890. doi: 10.1007/s40744-022-00440-1. Epub 2022 Mar 22. Rheumatol Ther. 2022. PMID: 35316515 Free PMC article.

  • Altered Fecal Metabolomics and Potential Biomarkers of Psoriatic Arthritis Differing From Rheumatoid Arthritis.

    Wang N, Yang L, Shang L, Liang Z, Wang Y, Feng M, Yu S, Li X, Gao C, Li Z, Luo J. Wang N, et al. Front Immunol. 2022 Feb 28;13:812996. doi: 10.3389/fimmu.2022.812996. eCollection 2022. Front Immunol. 2022. PMID: 35296075 Free PMC article.

References

    1. Zabotti A, Salvin S, Quartuccio L, et al. . Differentiation between early rheumatoid and early psoriatic arthritis by the ultrasonographic study of the synovio-entheseal complex of the small joints of the hands. Clin Exp Rheumatol 2016;34:459–65. - PubMed
    1. Verheul MK, Fearon U, Trouw LA, et al. . Biomarkers for rheumatoid and psoriatic arthritis. Clinical Immunology 2015;161:2–10. 10.1016/j.clim.2015.04.005 - DOI - PubMed
    1. Turesson C. Extra-articular rheumatoid arthritis. Curr Opin Rheumatol 2013;25:360–6. 10.1097/BOR.0b013e32835f693f - DOI - PubMed
    1. Villeneuve E, Nam JL, Bell MJ, et al. . A systematic literature review of strategies promoting early referral and reducing delays in the diagnosis and management of inflammatory arthritis. Ann Rheum Dis 2013;72:13–22. 10.1136/annrheumdis-2011-201063 - DOI - PubMed
    1. Gladman DD. Clinical features and diagnostic considerations in psoriatic arthritis. Rheumatic Disease Clinics of North America 2015;41:569–79. 10.1016/j.rdc.2015.07.003 - DOI - PubMed

LinkOut - more resources

  • Full Text Sources

    • Europe PubMed Central
    • HighWire
    • PubMed Central

  • Other Literature Sources

    • scite Smart Citations

  • Research Materials

    • NCI CPTC Antibody Characterization Program

  • Miscellaneous

    • NCI CPTAC Assay Portal

What are the major differences between psoriatic arthritis and rheumatoid arthritis?

In psoriatic arthritis, there is usually more inflammation in the spots where ligaments and tendons attach to bone. In rheumatoid arthritis, inflammation is more common in the joint lining.

How do you know if you have psoriatic arthritis or rheumatoid arthritis?

The signs and symptoms of psoriatic arthritis often resemble those of rheumatoid arthritis. Both diseases cause joints to become painful, swollen and warm to the touch. However, psoriatic arthritis is more likely to also cause: Swollen fingers and toes.

Can a person have psoriatic arthritis and rheumatoid arthritis?

Answer: It is certainly possible that a person could have both rheumatoid arthritis and psoriatic arthritis. However, doctors, including rheumatologists, generally avoid making multiple diagnoses when a single diagnosis could suffice.

What are the 5 types of psoriatic arthritis?

Psoriatic arthritis is categorized into five types: distal interphalangeal predominant, asymmetric oligoarticular, symmetric polyarthritis, spondylitis, and arthritis mutilans. The distal interphalangeal predominant type affects mainly the ends of the fingers and toes.

Related Posts

Whats the difference between full synthetic and synthetic blend
Difference between counter depth and standard refrigerator
Difference between standard and counter depth refrigerator
What is the difference in hodgkins and non hodgkins lymphoma
What is the difference between ssi and social security benefits
Whats the difference between confectioners sugar and powdered sugar
What is the difference between a ophthalmologist and an optometrist
Difference between paypal friends and family and goods and services
Whats the difference between a mobile home and a trailer
Whats the difference between a manufactured and a modular home

Toplist

Latest post

TAGs